Phase 2 Study of NBP For Patients With Acute Ischemic Stroke "SUNRISE"


Phase 2 Results N/A



  • Brott T, Bogousslavsky J. Treatment of acute ischemic stroke. N Engl J Med. 2000 Sep 7;343(10):710-22. Review. Pubmed ID:10974136
  • Chang Q, Wang XL. Effects of chiral 3-n-butylphthalide on apoptosis induced by transient focal cerebral ischemia in rats. Acta Pharmacol Sin. 2003 Aug;24(8):796-804. Pubmed ID:12904280
  • Chong Z, Feng Y. dl-3-n-butylphthalide reduces brain damage in mice with closed head injury. Chin Med J (Engl). 2000 Jul;113(7):613-6. Pubmed ID:11776030
  • Huang JZ, Chen YZ, Su M, Zheng HF, Yang YP, Chen J, Liu CF. dl-3-n-Butylphthalide prevents oxidative damage and reduces mitochondrial dysfunction in an MPP(+)-induced cellular model of Parkinson's disease. Neurosci Lett. 2010 May 14;475(2):89-94. doi: 10.1016/j.neulet.2010.03.053. Epub 2010 Mar 27. Pubmed ID:20347933
  • Liu XG, Feng YP. [Protective effect of dl-3-n-butylphthalide on ischemic neurological damage and abnormal behavior in rats subjected to focal ischemia]. Yao Xue Xue Bao. 1995 Dec;30(12):896-903. Chinese. Pubmed ID:8712015
  • Patel N, Rao VA, Heilman-Espinoza ER, Lai R, Quesada RA, Flint AC. Simple and reliable determination of the modified rankin scale score in neurosurgical and neurological patients: the mRS-9Q. Neurosurgery. 2012 Nov;71(5):971-5; discussion 975. doi: 10.1227/NEU.0b013e31826a8a56. Pubmed ID:22843133
  • Weimar C, Ho TW, Katsarava Z, Diener HC; German Stroke Study Collaboration. Improving patient selection for clinical acute stroke trials. Cerebrovasc Dis. 2006;21(5-6):386-92. Epub 2006 Feb 15. Pubmed ID:16490952
  • Yan CH, Zhang JT, Feng YP. [Protective effects of D-3-N-butylphthalide and L-3-N-butylphthalide on neuronal damage induced by KCl and NMDA in cultured rat cortical neurons]. Yao Xue Xue Bao. 1997 May;32(5):340-6. Chinese. Pubmed ID:11498868

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