Multimodal Treatment of Phonological Alexia: Behavioral & fMRI Outcomes

Completed

Phase 1/2 Results N/A

Trial Description

This study offers 90-120 hours of 1:1 training to improve reading skills in adults who have poor reading skills following a stroke. Specifically, this study is designed to improve skill in sounding out words for reading and spelling. The overall time commitment for participation in this study is approximately 11-30 weeks.

Detailed Description

The proposed study is a mixed-effects (single-subject ABA repeated-probe and small group elements) design with 90-120 hours of a modified multi-modal treatment of alexia replicated across up to 18 adults with post-stroke phonological alexia. The short-term goals of this research proposal includes the following: 1) determine if a modified multimodal treatment of phonological alexia can improve pseudoword reading skills (providing a basis from which training will also treat real word reading skills), 2) determine if a modified multimodal treatment of phonological alexia can improve real word reading skills, 3) determine how brain lesion extent and location relate to participants' response to treatment, and 4) identify relationships between changes in functional brain activity in specified regions of interest and participants' response to treatment.

Conditions

Interventions

  • One-on-one treatment of reading difficulties Behavioral
    Intervention Desc: Multimodal behavioral treatment focused on retraining sound to letter associations and skills in sounding out words when reading. Treatment has been pilot-tested in published papers since 1998.
    ARM 1: Kind: Experimental
    Label: 1
    Description: Adults with post-stroke reading difficulties (phonological alexia), >3 months post-stroke, native English speakers, able to undergo an MRI scan.
    ARM 2: Kind: Experimental
    Label: Arm 1
    Description: Adults with post-stroke reading difficulties (phonological alexia), >3 months post-stroke, native English speakers, able to undergo an MRI scan.
  • Functional Magnetic Resonance Imaging (fMRI) Radiation
    Intervention Desc: fMRI during reading pseudowords and during repeating pseudowords, as well as finger tapping (non-language task).
    ARM 1: Kind: Experimental
    Label: 2
    Description: fMRI during reading pseudowords and during repeating pseudowords, as well as finger tapping (non-language task)
    ARM 2: Kind: Experimental
    Label: Arm 2
    Description: fMRI during reading pseudowords and during repeating pseudowords, as well as finger tapping (non-language task)

Trial Design

  • Allocation: Non-Randomized
  • Masking: Open Label
  • Purpose: Treatment
  • Endpoint: Efficacy Study
  • Intervention: Single Group Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Behavioral testing and fMRI Language testing and fMRI sessions are conducted two weeks prior to treatment, immediately following end of treatment and 3 months after end of treatment. No

Sponsors