Multicentre Acute Stroke Trial-Italy "MAST-I"


Phase 3 Results


Streptokinase (alone or with aspirin) was associated with a greater number of fatalities at 10 days (odds ratio 2.7, 95% confidence interval 1.7-4.3, 2p<0.00001). Streptokinase (alone or with aspirin) and aspirin (alone or with streptokinase) both reduced the incidence of combined six-month case fatality and severe disability but the difference was not statistically significant (odds ratio for aspirin was 0.9, 95% CI 0.7-1.3, odds ratio for streptokinase was 0.9, 95% CI 0.6-1.3).