Multicentre Acute Stroke Trial-Italy "MAST-I"

Completed

Phase 3 Results

Trial Description

To determine whether, separately or together, streptokinase and aspirin have clinical benefits in acute ischemic stroke similar to those in acute myocardial infarction.

Interventions

Trial Design

Randomized, controlled, multi-center, open trial of 622 patients.

Patient Involvement

CT scan was required prior to randomization. Patients were then randomized with a 2x2 factorial design to either a 1-hour intravenous infusion of 1.5 MU streptokinase, 300 mg/day buffered aspirin for 10 days, both active treatments or neither.

Outcomes

Type Measure Time Frame Safety Issue
Primary Death or severe disability at 6 months.