Multi-modality MRI Study on Effect to Collateral Circulation and Blood Perfusion of Acute Cerebral Infarction by Human Urinary Kallidinogenase

Completed

Phase 2 Results N/A

Trial Description

Human urinary kallidinogenase can promote the establishment of collateral circulation in the ischemic penumbra due to the stenosis or occlusion of middle cerebral artery and then increase the perfusion.

Detailed Description

Patients with acute ischemic stroke will be given human urinary kallidinogenase .Then we will estimate the cerebral collateral circulation in ischemic regions and final infarct volume, comparing with traditional therapy such as Shuxuening injection, which will provide new evidence for the treatment of ischemic stroke. Perfusion Weighted Imaging(PWI) could be a method to reflect the infarction center and low perfusion of tissue.

Conditions

Interventions

  • Human Urinary Kallidinogenase Drug
    Other Names: HUK
    ARM 1: Kind: Experimental
    Label: Human urinary kallidinogenase and Shuxuening injection
    Description: Human urinary kallidinogenase 0.15PNA and Shuxuening injection 20mg, every day for 7 days.
  • Shuxuening injection Drug
    ARM 1: Kind: Experimental
    Label: Human urinary kallidinogenase and Shuxuening injection
    Description: Human urinary kallidinogenase 0.15PNA and Shuxuening injection 20mg, every day for 7 days.

Trial Design

  • Masking: Single Blind (Subject)
  • Purpose: Treatment
  • Endpoint: Efficacy Study
  • Intervention: Single Group Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Perfusion Weighted Imaging 7 days Yes

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