MR WITNESS-Multi-Center Safety Trial of IV rt-PA in Patients With Unwitnessed Stroke Onset "MR WITNESS"

Not yet recruiting

Phase N/A Results N/A

Summary of Purpose

(1) To study the safety of IV rt-PA in subjects with unwitnessed stroke onset with last known normal (LSN) time greater than 3 h but who show MRI evidence of onset less than or equal to 3.5 h, and who otherwise meet American Heart Association (AHA) rt-PA guidelines. (2) To validate novel MRI profiles to improve the sensitivity while maintaining high specificity for detecting subjects with stroke duration less than or equal to 3.5 h using data...

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 25 March 2010.

Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable
Start Date First Received 1st Completion Completion Verification Results

Trial Basics

Interventions

Sponsors

  • NIH

Trial Design

open-label, single-arm, multi-center Phase IIa safety study

Contacts

  • Ona Wu, Ph.D. (MGH) ona@nmr.mgh.harvard.edu, phone: (617) 643-3873, fax: (617) 643-3939, Shlee S. Song M.D.(NIH) songs3@ninds.nih.gov, phone (301)435-9321, fax (301)480-0413

    ona@nmr.mgh.harvard.edu, songs3@ninds.nih.gov