Motor Recovery in Recent Stroke Patients Treated With Amphetamine and Physical Therapy


Phase 2 Results N/A

Eligibility Criteria

Hemiparetic patients (right or left) (defined as a score of 55 or lower on Fugl-Meyer Scale) who had a single thromboembolic non-hemorrhagic infarction (documented by CT or MRI) 5 to 30 days before.
Patients will be recruited from referrals from the community particularly from Suburban Hospital.
Large hemorrhagic or brain stem stroke.
Multiple cerebral lesions with residual deficits.
Less than 5 days after stroke or greater than 30 days after stroke.
Age younger than 18 or older than 80 years.
History of head injury with loss of consciousness.
Terminal illness such as AIDS or cancer.
Severe neurological diseases other than stroke.
History of severe alcohol or drug abuse.
History of psychiatric illness.
Unstable cardiac dysrhythmia or unresponsive arterial hypertension (greater than 160/100 mmHg).
Untreated hyperthyroidism.
Receiving alpha-adrenergic antagonists or agonists.
Receiving major/minor tranquilizers, clonidine, prazosin, phenytoin, GABA, benzodiazepines, scopolamine, haloperidol, other neuroleptics, barbituates.
Degree of aphasia or cognitive deficit that makes patients unable to give informed consent.
Pregnancy. A pregnancy test will be done on admission.