Evaluating an innovative molecular imaging technique to visualize inflammation of the atherosclerotic plaque in patients with a recent ischemic stroke (<15 days) with carotid stenosis> 50%, by performing a Positron emission tomography-computed tomography (PET-CT) with PBR06 18F, a tracer for Translocator protein (TPSO).
More than one third of cerebral ischemic events are related to an atheromatous plaque. Inflammation, through a key player, the macrophage, is associated with increased metabolic activity of atherosclerotic plaque and its possible rupture. Inflammation within the plate is thus a marker of instability. These data underscore the importance of a prospective evaluation of inflammation with specific imaging with PET tracers inflammation.
- 18F-PBR06 Drug
Intervention Desc: Positron Emission Tomography / Computed Tomography (PET-CT) using 18F-PBR06 ARM 1: Kind: Experimental Label: Experimental arm
- PET-CT Device
ARM 1: Kind: Experimental Label: Experimental arm
- Masking: Open Label
- Purpose: Diagnostic
- Intervention: Single Group Assignment
|Type||Measure||Time Frame||Safety Issue|
|Primary||Correlation between the value of standardized uptake value (SUV) on PET-CT with 18F-PBR06 and the degree of macrophage infiltration at histological examination||15 days||No|
|Secondary||Levels of leukocyte and T lymphocyte inflammation of the plaque||15 days||No|
|Secondary||Plaque parameters composite||15 days||No|
|Primary||Correlation between the value of standardized uptake value (SUV) on PET-CT with 18F-PBR06 and the degree of macrophage infiltration at histological examination||15 days|