Modulation of Cerebral Blood Flow Using Quercetin, a Nutritional Supplement "Quercetin"

Completed

Phase 0 Results N/A

Trial Description

The purpose of this study is to find out if quercetin can increase blood levels of hypoxia-inducible transcription factor 1 (HIF-1 protein) and to see if there is a corresponding increase in blood flow to the brain.

Conditions

Interventions

  • Quercetin/placebo Dietary Supplement
    Intervention Desc: Quercetin 500mg once per day versus placebo
    ARM 1: Kind: Experimental
    Label: healthy young
    ARM 2: Kind: Experimental
    Label: healthy old

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
  • Purpose: Prevention
  • Endpoint: Pharmacodynamics Study
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Define change from baseline levels of HIF-1 concentration and 3 of its regulated proteins after 6 months of quercetin (versus placebo) dietary intake. 6 months No
Primary Determine change from baseline brain blood flow after 6 months of quercetin (versus placebo) dietary intake. 6 months No
Secondary Define change from baseline performance in a battery of cognitive tasks after 6 months of quercetin (versus placebo) dietary intake. 6 months No

Sponsors