Mirror Box Imaging Study

Recruiting

Phase N/A Results N/A

Trial Description

The purpose of this study is to evaluate the effects of mirror box therapy on upper extremity, motor recovery and motor functioning in patients that have suffered a stroke.

Detailed Description

Arm and hand weakness as a result of stroke occurs in approximately 70% of stroke survivors, with 30%-60% of patients being unable to fully recover functional use of their upper limbs. As recovery may be due to insufficient or inadequate therapeutic interventions, the progress and evaluation of upper limb treatment is currently being investigated.
Mirror Box therapy is a task orientated, non-invasive, economic and patient directed therapy for hemiparetic upper limb post stroke patients. The study is intended to evaluate cerebral reorganization by using mirror therapy. Movements of the stronger limb trick the brain into thinking that the weaker arm is moving and to stimulate the respective brain areas.
Patients are enrolled into two groups using standard upper limb rehabilitation for three weeks followed by standard rehabilitation plus Mirror Box for another three weeks (Group 1). Group 2 will receive the same therapy in inverted order.
Patients will receive clinical and functional assessment at baseline, three weeks and six weeks including brain MRI using functional resting state MRI.
The primary outcome is functional connectivity (correlation coefficient) at baseline and after treatment. Secondary endpoints include motor and functional recovery using outcome measures like Fugl Meyer assessment, Action Research Arm Test, grip and pincer strength. Further secondary endpoints are increase in sensorimotor cortex activation across the period of therapy and cortical reorganization.

Conditions

Interventions

  • Mirror Box Therapy Other
    Intervention Desc: In mirror box therapy the patient uses the reflection of their good arm to trick to brain into thinking that the effected arm is working.
    ARM 1: Kind: Experimental
    Label: Mirror box therapy
    Description: The participants in the mirror box therapy arm will receive mirror box therapy for 3 weeks for upper limb rehabilitation post stroke.

Trial Design

  • Allocation: Randomized
  • Masking: Single Blind (Subject)
  • Purpose: Treatment
  • Endpoint: Efficacy Study
  • Intervention: Crossover Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Change in brain connectivity will be assessed by resting-state fMRI Baseline, 3 weeks and at 6 weeks Yes
Secondary Activity of daily living will be assessed with Barthel index. Baseline, 3 weeks and at 6 weeks No
Secondary Function of the affected hemiplegic upper limb will be assessed with action research arm test Baseline, 3 weeks and at 6 weeks No
Secondary Impairment in the hemiplegic upper limb will be assessed with Fugl Meyer test. Baseline, 3 weeks and at 6 weeks No
Secondary Grip strength will be assessed using hand dynamometer Baseline, 3 weeks and at 6 weeks No

Sponsors