MIDNOR-TIA - a Study of 600 Patients With Transient Ischemic Attack "MIDNOR-TIA"

Completed

Phase N/A Results N/A

Trial Description

Patients with a transient ischemic attack (TIA) are at high risk of stroke. Rapid assessment and treatment can reduce the risk. Several international guidelines recommend a test, the ABCD2 score, to identify TIA patients with low and high risk for stroke. The main purpose of this study is to investigate stroke risk after TIA in both short (1 week) and long term (3 months/1 year), and to assess whether the Age, Blood pressure, Clinical features, Duration of TIA, Diabetes (ABCD2) score is a sufficient tool for predicting stroke risk. Secondary aims are to explore whether adopting imaging modalities (ultrasound, MRI) and biological markers of blood into a risk score could improve the predictive value of the ABCD2 score and still be feasible in a daily clinical practice. Further on overall risk factors in TIA patients, and the incidence of other vascular events will be studied. A substudy designed as a randomised controlled trial evaluates pharmaceutical counseling in a subset of participants. Cost-benefit analysis, and a long-term follow-up (5 years) is planned.

Conditions

Trial Design

  • Observation: Cohort
  • Perspective: Prospective
  • Sampling: Non-Probability Sample

Trial Population

Patients referred to a hospital in Central Norway with a recent probable or possible transient ischemic attack

Outcomes

Type Measure Time Frame Safety Issue
Primary Number of patients presenting with stroke within 1 week after transient ischemic attack 1 week No
Secondary Number of patients presenting with stroke within 3 months after transient ischemic attack 3 months No
Secondary Correlation between the ABCD2 score and the incidence of stroke within 1 week after transient ischemic attack 1 week No
Secondary Correlation between the ABCD2 score and the incidence of stroke within 3 months after transient ischemic attack 3 months No
Secondary Incidence of other vascular events within 1 week after transient ischemic attack 1 week No
Secondary Cost-benefit analysis 1 year No
Secondary Number of patients presenting with stroke within 1 year after transient ischemic attack 1 year No
Secondary Correlation between the ABCD2 score and the incidence of stroke within 1 year after transient ischemic attack 1 year No
Secondary Incidence of other vascular events within 3 months after transient ischemic attack 3 months No
Secondary Incidence of other vascular events within 1 year after transient ischemic attack 1 year No

Biospecimen Retention:Samples Without DNA - Blood samples

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