To determine the efficacy and safety of methylphenidate in acute stroke rehabilitation.
- Methylphenidate (Ritalin)Drug
Intervention Desc: CNS stimulant
Prospective, randomized, double-blind, placebo-controlled study involving 21 patients at a single center.
Patients were consecutively admitted to a community-based rehabilitation unit where they received a three-week treatment of methylphenidate (or placebo) in conjunction with physical therapy. Methylphenidate was started at 5mg and increased gradually to 30mg and discontinued before discharge.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Mood measures included the Hamilton Depression Rating Scale (HAM-D) and Zung Self-Rating Depression Scale (ZDS). Cognitive status was evaluated using the Mini-Mental State Exam (MMSE). Motor functioning was assessed using the Fugl-Meyer Scale (FMS) and a modified version of the Functional Independence Measure (M-FIM). All measures were administered pretreatment and weekly thereafter.|