Metabolic Imaging in Carotid Atherosclerosis "MICA"

Recruiting

Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

- Patients with carotid stenosis due to undergo carotid endarterectomy.

Exclusion Criteria

- Patients with new stroke and a modified Rankin score >3
- Chronic Kidney Disease with eGFR of <30 mL/min/1.73m2
- Pregnant women
- Poorly controlled diabetes mellitus (HbA1c > 8.5%) or diabetes mellitus requiring insulin
- Prior ipsilateral carotid intervention
- Prior neck irradiation
- Inability to tolerate the supine position
- Participation in the study would result in delay to surgery
- Psychiatric illness/social situations that would limit compliance with study requirements
- Specific contraindications to MRI (e.g. pacemaker)
- History of allergic reaction attributed to ferumoxytol or similar
- Known or suspected iron overload (genetic haemochromatosis or history of multiple transfusions)
- History of allergic reaction attributed to 18F-FDG or 18F-NaF or similar
- History of allergic reaction to iodine or iodine-based contrast media