Mechanisms of Walking Recovery After Stroke

Recruiting

Phase N/A Results N/A

Trial Description

Subjects with stroke will have behavioral testing and brain imaging before and after a 4-week control period and a 4-week exercise intervention.

Detailed Description

Subjects with stroke will have behavioral testing and brain imaging before and after a 4-week control period and a 4-week exercise intervention using high-intensity interval training.

Conditions

Interventions

  • No intervention Behavioral
    Intervention Desc: No intervention
    ARM 1: Kind: Experimental
    Label: Arm 1
    Description: 4-week control period with no intervention and 4-weeks of high-intensity interval training
  • High-intensity interval training Behavioral
    Intervention Desc: High-intensity walking exercise using bursts of concentrated effort alternated with recovery periods
    ARM 1: Kind: Experimental
    Label: Arm 1
    Description: 4-week control period with no intervention and 4-weeks of high-intensity interval training

Trial Design

  • Masking: Open Label
  • Purpose: Basic Science
  • Intervention: Single Group Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary walking speed Change from 4-weeks to 8-weeks No
Secondary gait symmetry baseline, 4 weeks, 8 weeks No
Secondary metabolic cost of gait baseline, 4 weeks, 8 weeks No
Secondary aerobic capacity baseline, 4 weeks, 8 weeks No
Secondary NIH toolbox - cognition domain baseline, 4 weeks, 8 weeks No
Secondary NIH toolbox standing balance test baseline, 4 weeks, 8 weeks No
Secondary Stroke and Aphasia Quality of Life Scale baseline, 4 weeks, 8 weeks No
Secondary brain locomotor network activation baseline, 4 weeks, 8 weeks No
Secondary brain locomotor network connectivity baseline, 4 weeks, 8 weeks No
Secondary walking capacity baseline, 4 weeks, 8 weeks No
Secondary daily walking activity baseline, 4 weeks, 8 weeks No

Sponsors