Mechanisms of Neuromuscular Fatigue Post Stroke


Phase 0 Results N/A

Eligibility Criteria

Inclusion Criteria

- be at least 18 years of age
- Cognitively able to give informed consent Stroke
-≥ 6 months post diagnosis of unilateral cortical stroke
- residual leg paresis

Exclusion Criteria

- chronic low back or hip pain
- major psychiatric disorders (e.g. depression
- substance abuse
- head trauma
- neurodegenerative disorder
- any uncontrolled medical disorder (e.g. hypertension)
- taking any medication or supplement (e.g. St. John's Wort) that has 5-HT or NE mechanisms of action(including Monoamine oxidase inhibitors (MAO) inhibitors)
- narrow angle glaucoma
- chronic liver or kidney disorders Stroke
- history of multiple strokes
- people who are unable to follow 2 step commands
- people who cannot walk ≥ 10 ft without physical assistance.