Mechanisms of Arm Recovery in Stroke Patients With Hand Paralysis

Recruiting

Phase N/A Results N/A

Trial Description

This study examines the effect of non-invasive brain stimulation targeting different brain areas on movement of the affected arm post-stroke. Participants will receive stimulation to each of 3 different brain areas combined with a session of arm exercise.

Detailed Description

Small improvements in affected arm movement can be made with intensive physical practice. These improvements could potentially be enhanced by combining non-invasive brain stimulation with practice.
To develop such an intervention, it is necessary to understand which brain areas should be stimulated in which types of patients. It is probably more beneficial to target one side of the brain vs. the other, for example, depending on the characteristics of the stroke.
This study will examine the effect of stimulating one side of the brain vs. the other on the amount of improvement that occurs from physically practicing functional arm movements.

Conditions

Interventions

  • Unaffected Transcranial Magnetic Stimulation Procedure
    Intervention Desc: Non-invasive brain stimulation to unaffected hemisphere site prior to practice
    ARM 1: Kind: Experimental
    Label: Unaffected Hemisphere
    Description: Application of "Unaffected Transcranial Magnetic Stimulation" to unaffected hemisphere site prior to physical practice
  • Affected Transcranial Magnetic Stimulation Procedure
    Intervention Desc: Non-invasive brain stimulation to affected hemisphere site prior to practice
    ARM 1: Kind: Experimental
    Label: Affected Hemisphere
    Description: Application of "Affected Transcranial Magnetic Stimulation" to affected hemisphere site prior to physical practice
  • Control Transcranial Magnetic Stimulation Procedure
    Intervention Desc: Non-invasive brain stimulation to control site prior to practice
    ARM 1: Kind: Experimental
    Label: Control Site
    Description: Application of "Control Transcranial Magnetic Stimulation" to control site prior to practice

Outcomes

Type Measure Time Frame Safety Issue
Primary Change in movement time Baseline and 1 Day
Secondary Change in maximum reaching distance Baseline and 1 Day
Secondary Change in hand path kinematics Baseline and 1 Day

Sponsors