Mechanisms in Heart Failure With Normal EF "HFpEF"


Phase N/A Results N/A

Summary of Purpose

The guiding hypotheses are that (1) mechanisms in addition to diastolic dysfunction, while normal at rest, are compromised with stress, leading to symptoms of HF, and (2) that an increased proportion of the increase in LV diastolic pressures seen in HFpEF is mediated via exaggerated pericardial/right heart-LV coupling (restraint).

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 6 February 2012.

1 Nov 2007 21 Dec 2007 1 Dec 2011 1 Dec 2011 1 May 2011 Unavailable
Start Date First Received 1st Completion Completion Verification Results

Trial Basics




Trial Design

  • Observation: Case Control
  • Perspective: Prospective
  • Sampling: Non-Probability Sample