Mayo Asymptomatic Carotid Endarterectomy Study Group "MACE"


Phase N/A Results

Eligibility Criteria

Inclusion Criteria

No history of symptoms of cerebral or retinal ischemic disease, presence or absence of localized carotid bruits, evidence of pressure-significant lesions in one or both internal carotid systems on ocular pneumoplethysmography and carotid stenosis but not occlusion on duplex ultrasound scans or intravenous digital subtraction angiograms.

Exclusion Criteria

Less than 18 years of age or greater than 79 years of age, women of childbearing age, contraindication to aspirin, prior allergic reaction to contrast dye, unstable angina or myocardial infarction within previous 6 months, potential sources of cardiac embolus, moderate to severe congestive heart failure, severe obstructive pulmonary disease, cancer other than of the skin, terminal illness, dementia or psychiatric illness precluding informed consent, other non-atherosclerotic reasons for carotid stenosis, hematologic or systemic diseases that might cause episodes of focal cerebral ischemia, renal failure, uncontrolled hypertension or diabetes.