Mayo Asymptomatic Carotid Endarterectomy Study Group "MACE"


Phase N/A Results

Trial Description

To compare the effects of carotid endarterectomy with medical treatment of low-dose aspirin in patients with asymptomatic carotid stenosis.


  • Endarterectomy, carotid (CEA)Procedure/Surgery
    Intervention Desc: Surgical therapy to remove atherosclerotic plaque in narrowed carotid arteries.

Trial Design

Prospective, randomized, controlled trial of 71 patients.

Patient Involvement

Patients were randomized to either the surgical group or medical group. In the surgical group, a unilateral or bilateral carotid endarterectomy angiography was performed if it had not been done prior to randomization. Aspirin use was discouraged in the surgical group. In the medical group, patients received aspirin 80 mg daily. All patients received treatment for other cerebrovascular risk factors as needed.


Type Measure Time Frame Safety Issue
Primary Transient ischaemic attack, ischemic or hemorrhagic stroke in any vascular territory, death.
Secondary Myocardial infarction.


National Institute for Neurological Disorders and Stroke, NIH