In this study the investigators wish to explore the potential neuroprotective effects of acute oral supplementation of lycopene, a natural anti-oxidant derived from tomatoes, on cerebral vasospasm and autoregulation, and examine whether any improvements translate into a reduction of biochemical markers of vascular injury and inflammation a decrease in the prevalence of secondary strokes following subarachnoid haemorrhage.
- Placebo Drug
Intervention Desc: starch ARM 1: Kind: Experimental Label: Placebo
- Lycopene Drug
Intervention Desc: 30 mg oral, daily, for 21 days ARM 1: Kind: Experimental Label: Active
- Allocation: Randomized
- Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
- Purpose: Prevention
- Endpoint: Efficacy Study
- Intervention: Parallel Assignment
Patients will be randomized to one of two arms: Lycopene 30 mg oral, daily, for 21 days or placebo orally daily for 21 days.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Incidence of vasospasm Duration of impaired autoregulation on TCD|
|Primary||Incidence of vasospasm||Daily for 21 days||No|
|Primary||Duration of impaired autoregulation measured with transcranial Doppler||Daily for 21 days||No|
|Secondary||Level of biochemical markers of vascular injury: LDL, oxy-LDL, CRP, circulating endothelial cells, endothelial progenitor cells||Days: 0, 3, 6, 12, 14, 21||No|