To investigate whether the apparent protective effect of propranolol on cerebral function in patients with subarachnoid hemorrhage also applied to patients with acute stroke.
- Atenolol (Tenormin)Drug
Other Names: tenormin Intervention Desc: Beta-adrenergic receptor antagonist (beta-blocker); anti-hypertensive
- Propranolol (Inderal)Drug
Intervention Desc: Beta-adrenergic receptor antagonist (beta-blocker) antihypertensive
Randomized trial of 302 patients.
Patients were randomly assigned to receive atenolol (50 mg daily), slow release propranolol (80 mg daily), or matching placebo capsules for three weeks or until discharge, whichever occurred first.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Neurological assessment at entry, day 8, and 1 and 6 months. Full functional assessments from day 8 onwards measured by activities of daily living and comparison of the number of days spent in hospital, or under nursing care during 6-month follow-up period.|