Looking For Genetic and Environmental Risk Factors and Therapeutic Aspects in Cervical Artery Dissections "CADISP"

Active, not recruiting

Phase N/A Results N/A

Eligibility Criteria

GROUP1:

Inclusion Criteria

- Typical radiological aspect of dissection* in a cervical artery (carotid and/or vertebral);* Mural hematoma, pseudoaneurysm, long tapering stenosis, intimal flap, double lumen, or occlusion > 2 cm above the carotid bifurcation revealing a pseudo aneurysm or a long tapering stenosis after recanalisation
- Written informed consent

Exclusion Criteria

- Purely intracranial dissection
- Dissection occurring after an endovascular procedure
- Known mendelian genetic disorder that can explain the dissection (e.g. vascular Ehlers-Danlos syndrome)
GROUP2:
Inclusion Criteria:
- Recent ischemic stroke
- No signs of CAD on extracranial duplex sonography and angiography (digital subtraction or magnetic resonance or CT), performed < 7 days after the stroke
- Written informed consent
Exclusion Criteria:
- Possible cerebral ischemia but normal cerebral imaging
- CAD cannot be ruled out (e.g.persistent arterial occlusion without mural hematoma)
- Endovascular or surgical procedure on the coronary, cervical or cerebral arteries during the 48 hours preceding the cerebral infarction
- Cardiopathies with a very high embolic risk (Mechanical prosthetic valves, mitral stenosis with atrial fibrillation, intracardiac tumor, infectious endocarditis, myocardial infarction<4 months)
- Arterial vasospasm following a subarachnoid haemorrhage
- Auto-immune disease possibly responsible for the cerebral infarction
- Known monogenic disease responsible for the cerebral infarction
GROUP3:
Inclusion criteria:
- Individuals from the general population without history of stroke, dissections in any artery, transient ischemic attack, coronary artery disease, peripheral artery disease
- Written informed consent