Long-term anticoagulation in stroke patients with atrial fibrillation

Completed

Phase N/A Results

Trial Description

To test the efficacy of warfarin in the secondary prevention of non-embolic stroke among patients with atrial fibrillation.

Interventions

  • Warfarin (Coumadin┬«)Drug
    Intervention Desc: Anticoagulant (Vitamin K antagonist)

Trial Design

Controlled trial of 386 patients.

Patient Involvement

Patients with atrial fibrillation were characterized for stroke subtype on clinical, neuroimaging, carotid ultrasonographic and echocardiographic criteria. Eligible patients were treated with adjusted dose warfarin (INR 2.0-3.0). Aspirin (75-300 mg daily) was used in patients with contraindications or refusing anticoagulation. Patients were followed for 2 years.

Outcomes

Type Measure Time Frame Safety Issue
Primary Rate of recurrent stroke and minor bleeding complications.