Local Versus Systemic Thrombolysis for Acute Ischemic Stroke (SYNTHESIS)


Phase 3 Results

Summary of Purpose

The purpose of this study is to determine whether intra-arterial rt-PA within 6 hours from an ischemic stroke onset, compared with intravenous infusion of the same drug within 3 hours, increases the proportion of independent survivors at 3 months.

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 24 October 2012.

1 Jan 2004 5 Oct 2007 1 Jan 2008 1 Jan 2008 1 Oct 2012 Unavailable
Start Date First Received 1st Completion Completion Verification Results

Trial Design

  • Allocation: Randomized
  • Masking: Open Label
  • Purpose: Treatment
  • Endpoint: Safety/Efficacy Study
  • Intervention: Parallel Assignment


  • Alfonso Ciccone, MD