Kinetics of Plasma and Serum Levels of Brain-Derived Neurotrophic Factor (BDNF) in Patients With Ischemic Stroke "BDNF"

Completed

Phase N/A Results N/A

Trial Description

The aim of this study is to show for the first time that treatment with intravenous fibrinolysis using rt-PA in patients with recent ischemic stroke is accompanied by increases in circulating levels of BDNF, which may reflect an increase in BDNF synthesis in the brain.
The analysis of the recovery of functional and cognitive abilities as well as mood at 3 months will allow us to study the impact of BDNF on these parameters. Thus, depending on the results obtained, circulating BDNF could serve as an early marker of these.

Conditions

Interventions

  • Blood samples Other
    ARM 1: Kind: Experimental
    Label: Patients with fibrinolysis
    ARM 2: Kind: Experimental
    Label: Patients without fibrinolysis
  • Cerebral MRI Other
    ARM 1: Kind: Experimental
    Label: Patients with fibrinolysis
    ARM 2: Kind: Experimental
    Label: Patients without fibrinolysis

Trial Design

  • Allocation: Non-Randomized
  • Masking: Open Label
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Measurement of plasma levels of BDNF Change from baseline at Day1, Day 7 and Month 3 No
Primary Measurement of serum levels of BDNF Change from baseline at Day1, Day 7 and Month 3 No

Sponsors