Japanese Nonvalvular Atrial Fibrillation-Embolism Secondary Prevention Cooperative Study "JNAF-ESP"


Phase N/A Results

Summary of Purpose

To determine the efficacy and safety of conventional- and low-intensity warfarin therapy in non-valvular atrial fibrillation (NVAF).

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 26 July 2001.

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Start Date First Received 1st Completion Completion Verification Results

Trial Basics



  • Japan Cardiovascular Research Foundation, research grants for Cardiovascular Disease (6A-1, 9A-8) from the Ministry of Health and Welfare of Japan

Trial Design

Prospective, randomized, open-label trial of 115 patients at 19 centers.


  • Takenori Yamaguchi, MD, Director General of the Hospital, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka