IV vs. IA tPA (Activase) in Acute Ischemic Stroke With CTA Evidence of Major Vessel Occlusion


Phase N/A Results

Eligibility Criteria

Inclusion Criteria:Subjects will be eligible if the following criteria are met:
- Ability to provide written informed consent and comply with study assessments for the full duration of the study.
- Age > 18 years
- NIHSS ≥ 4 or isolated aphasia or isolated hemianopsia

Exclusion Criteria

- NIHSS >30
- Coma
- Rapidly improving symptoms
- History of stroke in the last 6 weeks
- Seizure at onset
- Subarachnoid Hemorrhage (SAH ) or suspected SAH
- Any history of Intracrannial Hemorrhage (ICH)
- Neoplasm
- Septic embolism
- Surgery, biopsy, trauma or LP in last 30 days
- Head trauma in the last 90 days
- Bleeding diathesis, or INR >1.7 or PTT >1.5 times baseline or platelet <100K
- SBP >180 or DBP ≥100 despite treatment with 3 doses of IV Labetalol (10-20 mg Q10")
- Lacunar stroke syndrome
- CT: Hemorrhage, tumor (except small meningioma), significant mass effect, midline shift, acute hypodensity or >1/3 MCA territory sulcal effacement
- Radiological contrast hypersensitivity
- Angiographic: Dissection, lack of access, lack of occlusion, or nonatherosclerotic arteriopathy