Ischemic Conditioning as an Intervention to Improve Motor Function in Chronic Stroke

Recruiting

Phase N/A Results N/A

Trial Description

The investigators will test whether an intervention called ischemic conditioning can improve paretic leg motor function in chronic stroke subjects.

Detailed Description

This study will study ischemic conditioning (IC) as an intervention to improve motor function post-stroke. IC is a well studied, well tolerated intervention which has been shown to improve regional blood flow, motor neuron excitability and muscle function in multiple patient groups and in young, healthy subjects. Because IC targets three physiological systems which are all affected by stroke, the investigators hypothesize that repeated bouts of IC will result in improved motor function of the paretic leg.

Conditions

Interventions

  • Sham Device
    Intervention Desc: Inflation of blood pressure cuff to 25 mmHg on paretic leg. 1 session: 5 minutes of inflation, 5 minutes deflation, repeated 5 times. Maximum 12 sessions over 4 weeks.
    ARM 1: Kind: Experimental
    Label: Sham
    Description: The investigators will perform sham ischemic conditioning on the paretic leg by inflating a blood pressure cuff to only 25 mmHg on the leg for 5 minutes. This will be repeated for 5 cycles, with 5 minutes of rest between each cycle. The intervention will be performed for a maximum of 12 times within a 4 week period.
  • Ischemic conditioning Device
    Other Names: Doctormate, IPC-906
    Intervention Desc: Inflation of blood pressure cuff to 225 mmHg on paretic leg. 1 session: 5 minutes of inflation, 5 minutes deflation, repeated 5 times. Maximum 12 sessions over 4 weeks.
    ARM 1: Kind: Experimental
    Label: Ischemic Conditioning
    Description: The investigators will perform ischemic conditioning on the paretic leg by inflating a blood pressure cuff to 225 mmHg to occlude blood flow to the leg for 5 minutes. This will be repeated for 5 cycles, with 5 minutes of rest between each cycle. The intervention will be performed for a maximum of 12 times within a 4 week period.

Outcomes

Type Measure Time Frame Safety Issue
Primary Leg Muscle Strength Within 1 year of admission into the study
Secondary Leg Muscle Fatigue Within 1 year of admission into the study

Sponsors