Intravenous Thrombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke


Phase 1 Results

Summary of Purpose

The purpose of this trial is to evaluate if it is safe to use tissue plasminogen activator (tPA) within 6 hours of stroke onset when combined with hypothermia.

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 11 January 2011.

1 Oct 2003 26 Jan 2006 1 Oct 2008 1 May 2009 1 Jan 2009 Unavailable
Start Date First Received 1st Completion Completion Verification Results

Trial Design

  • Allocation: Randomized
  • Masking: Open Label
  • Purpose: Treatment
  • Endpoint: Safety Study
  • Intervention: Factorial Assignment


  • Thomas Hemmen, MD, PhD Assistant Professor Director, UCSD Stroke Center University of California, San Diego Department of Neurosciences Medical Offices North, 3rd Floor, Suite 3 200 West Arbor Drive San Diego, CA 92103-8466 Telephone: (619)543-7760 Telefax: (619)543-7771 Alyssa Chardi University of California San Diego Stroke Center 200 W. Arbor Drive- 8466 San Diego, CA 92102 Phone: (619) 543-7760 Email: OR Karen Rapp, RN UCSD Stroke Center