To evaluate the efficacy and tolerability of two different intravenous doses of nimodipine in aneurysmal subarachnoid hemorrhage.
- Nimodipine (Nimotop®)Drug
Intervention Desc: Calcium channel blocker (L-type calcium channels)
Multicenter, prospective, randomized, stratified, double-blind, dose-comparison study of 204 patients at 11 European centers. Stratification was based on Hunt and Hess grade and center.
All patients who had Hunt and Hess grades of I to III were operated upon; patients who had poor Hunt and Hess grades (IV-V) were operated on according to the surgeon's choice. Patients were randomized to receive either 2 or 3 mg/h nimodipine intravenously via a central catheter. Treatment was initiated either before or during operation.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Glasgow Outcome Scale score at the end of treatment and at 6 months.|