Intravenous nimodipine and early aneurysm surgery

Completed

Phase N/A Results

Trial Description

To evaluate the efficacy and tolerability of two different intravenous doses of nimodipine in aneurysmal subarachnoid hemorrhage.

Interventions

  • Nimodipine (NimotopĀ®)Drug
    Intervention Desc: Calcium channel blocker (L-type calcium channels)

Trial Design

Multicenter, prospective, randomized, stratified, double-blind, dose-comparison study of 204 patients at 11 European centers. Stratification was based on Hunt and Hess grade and center.

Patient Involvement

All patients who had Hunt and Hess grades of I to III were operated upon; patients who had poor Hunt and Hess grades (IV-V) were operated on according to the surgeon's choice. Patients were randomized to receive either 2 or 3 mg/h nimodipine intravenously via a central catheter. Treatment was initiated either before or during operation.

Outcomes

Type Measure Time Frame Safety Issue
Primary Glasgow Outcome Scale score at the end of treatment and at 6 months.