Intraoperative, intracisternal tissue plasminogen activator for the prevention of vasospasm


Phase N/A Results

Eligibility Criteria

Inclusion Criteria

Ruptured saccular aneurysms causing severe SAH, >= 18 years of age, able to have surgery and drug administration within 72 hours of SAH, informed consent.

Exclusion Criteria

SAH due to nonsaccular aneurysm; coexistent medical, neurological or psychiatric illness that would interfere with patient assessment; history of hepatic or bleeding disorders; pretreatment laboratory evidence of bleeding diathesis; multiple aneurysms that could not be repaired all at once and/or multiple aneurysms in which it was impossible to determine with certainty which aneurysm had bled.