Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial "ICH ADAPT"

Completed

Phase 2 Results N/A

Eligibility Criteria

Inclusion Criteria

- Age ≥18 years
- Acute primary ICH demonstrated with CT scan
- Onset ≤ 24 h prior to randomization

Exclusion Criteria

- Contraindication to BP reduction i.e., severe arterial stenosis or high-grade stenotic valvular heart disease
- Indication for urgent BP reduction i.e., hypertensive encephalopathy, or aortic dissection
- Definite evidence that the ICH is secondary to underlying cerebral or vascular pathology, i.e., AVM, aneurysm, tumour, trauma, vasculitis, or hemorrhagic transformation of an ischemic infarct
- Previous ischemic stroke within 30 days of current event NB: Prior ICH is not an exclusion criterion
- Planned surgical resection of hematoma NB: Extraventricular Drain placement is not an exclusion criterion
- Contraindication to CT perfusion imaging (i.e. contrast allergy, metformin use or Creatinine >160 μmol/l)