Intra-arterial Versus Systemic Thrombolysis for Acute Ischemic Stroke "SYNTHESIS EXP"

Completed

Phase 3 Results N/A

Summary of Purpose

SYNTHESIS is a pragmatic multicenter randomized controlled trial (RCT), open-label, with blinded follow-up aiming to determine whether loco-regional intra-arterial (IA) with recombinant tissue-plasminogen activator (rt-PA) and/or mechanical devices, as compared with systemic intravenous (I.V.) infusion of rt-PA within 3 hours of ischemic stroke, increases the proportion of independent survivors at 3 months.

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 24 April 2014.

1 Feb 2008 18 Mar 2008 1 Feb 2009 1 Jul 2012 1 Apr 2014 Unavailable
Start Date First Received 1st Completion Completion Verification Results

Trial Design

  • Allocation: Randomized
  • Masking: Open Label
  • Purpose: Treatment
  • Endpoint: Safety/Efficacy Study
  • Intervention: Parallel Assignment

Contacts

  • Alfonso Ciccone, MD