Interhemispheric Interactions Associated With Performance of Voluntary Movements in Patients With Stroke Motor Disability

Completed

Phase N/A Results N/A

Eligibility Criteria

- INCLUSION CRITERIA:
- Age 21 and above
- Willingness and ability to perform all tasks as requested
- For stroke patients, history of one, unilateral stroke greater than 6 months prior to enrollment, with initial hand paresis that has recovered to the point of being able to perform the motor task
EXCLUSION CRITERIA:
- Inability to perform any of the requested tasks
- Folstein mini-mental state exam (Folstein. 1976) score of 23 or less.
Diagnosis of severe uncontrolled medical problems (e.g. cardiovascular disease, severe rheumatoid arthritis, active joint deformity of arthritic origin, active cancer or renal disease, any kind of end-stage pulmonary or cardiovascular disease) or a deteriorated condition due to age
- Diagnosis of alcohol dependence at the time or in the six months prior to participation as made by a community or NIH independent licensed practitioner
- Diagnosis of major depressive disorder at the time or in the six months prior to participation as made by a community or NIH independent licensed practitioner
- Pacemakers, implanted pumps, or stimulators, such as cochlear implants or metal objects inside the eye or skull aside from dental implants
- Metal in the cranium except mouth
- Metal fragments from occupational exposure or surgical clips in or near the brain
- Eye, blood vessel, cochlear or eye implants
- History of epilepsy
- Pregnancy
- For healthy volunteers, diagnosis of any neurologic disorder as made by a community or NIH independent licensed practitioner
- For healthy volunteers, active use of any anti-depressant, anti-convulsive, neuroleptic, or psycho-stimulant medications
- For stroke patients: more than one stroke, brainstem or cerebellar stroke, or any history of bilateral paresis
- Lack of capacity to give informed consent