Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage


Phase N/A Results

Eligibility Criteria

Inclusion Criteria

- Aged 18 years or above
- Acute stroke due to spontaneous ICH confirmed by clinical history & CT scan
- At least 2 systolic BP measurements of >/=150mmHg and - Able to commence randomly assigned BP lowering regimen within 6 hours of stroke onset
- Able to be actively treated and admitted to a monitored facility e.g. HDU/ICU/acute stroke unit

Exclusion Criteria

- Known definite contraindication to an intensive BP lowering regimen
- Known definite indication for intensive BP lowering regimen as (or more) intensive than the active treatment arm
- Definite evidence that the ICH is secondary to a structural abnormality in the brain
- Previous ischaemic stroke within 30 days
- A very high likelihood that the patient will die within the next 24 hours on the basis of clinical and/or radiological criteria
- Known advanced dementia or significant pre-stroke disability
- Concomitant medical illness that would interfere with outcome assessments and follow up
- Already booked for surgical evacuation of haematoma
- Previous participation in this trial or current participation in another investigational drug trial
- A high likelihood that the patient will not adhere to the study treatment and follow up regimen