Inhalatorial Sedation in Patient With Subarachnoid Hemorrhage (SAH) Versus Conventional Intravenous Sedation "GAS-SAH"

Completed

Phase 4 Results N/A

Trial Description

Recent study has shown that inhalatory sedation is a practicable, effective and not risky method in Intensive Care Unit. Sevoflurane effect on cerebral system have been described in previous studies: it causes an increasing of cerebral blood flow and a decrease of oxygen cerebral consumption. Clinical strategy for Subarachnoid Hemorrhage is orientated to increase cerebral blood flow to limit vasospasm phenomena after SAH. Scope of this study is to evaluate the Cerebral Blood Flow variation associated to Isoflurane sedation versus conventional sedation with propofol .

Conditions

Interventions

  • Propofol Drug
    Other Names: Diprivan
    Intervention Desc: Propofol(3-4 mg/kg/ora)administrated for 2 hours.
    ARM 1: Kind: Experimental
    Label: Propofol
    Description: Propofol(3-4 mg/kg/ora)administrated for 2 hours.
  • Isoflurane Drug
    Intervention Desc: Isoflurane inhalatorial administration for 2 hours at 0.8-1.0% Minimum Alveolar Concentration
    ARM 1: Kind: Experimental
    Label: Isoflurane
    Description: Isoflurane inhalatorial administration for 2 hours at 0.8-1.0% Minimum Alveolar Concentration

Trial Design

  • Allocation: Non-Randomized
  • Masking: Open Label
  • Purpose: Treatment
  • Endpoint: Efficacy Study
  • Intervention: Crossover Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Cerebral Blood Flow after 2 hours of drug administration No

Sponsors