Influence of Theta Burst Stimulation and Carbidopa-Levodopa on Motor Performance in Stroke Patients

Completed

Phase N/A Results N/A

Eligibility Criteria

- INCLUSION CRITERIA:
PATIENTS:
- Age 18 - 90
- Ischemic cerebral infarction more than 6 months prior to testing not involving cortical motor areas
- Initial severe paresis (MRC Grade 2 or less in hand muscles) with considerable motor recovery
- Ability to make ballistic thumb abduction or wrist extension movements in the affected hand
HEALTHY SUBJECTS:
- Age 18 - 90
- Right handed
- Able to concentrate and to perform the tasks required
EXCLUSION CRITERIA:
PATIENTS:
- More than one ischemic stroke, or any hemorrhagic stroke
- Large cortical stroke
- Significant cognitive impairment, defined as a Mini Mental State Examination score of 23 or less
- History of seizures or other neurological illness (except stroke)
- History of alcohol or drug abuse
- Inability to make necessary thumb abduction or wrist extension movements
- Current or recent use of neuroleptic medication, tricyclic anti-depressants or monoamine oxidase inhibitors
- History of narrow angle glaucoma
- Contraindications to TMS - presence of cardiac pacemaker, intracardiac lines, implanted pumps or stimulators, or metal objects inside the eye or skull
- Pregnancy (as the effects of TBS on the fetus are as yet unknown)
- Uncontrolled medical (e.g. cardiovascular disease expressed as uncontrolled arrhythmias, shortness of breath, or overt signs of severe peripheral edema at the initial neurological exam, severe rheumatoid arthritis, arthritic joint deformity, active cancer or renal disease), or psychiatric problems (defined as having received medical treatment from a psychiatrist).
HEALTHY SUBJECTS:
- Contraindications to TMS (as above)
- Pregnancy (see above)
- History of seizures or other neurological illness
- History of alcohol or drug abuse
- History of depression / psychiatric illness requiring use of anti-psychotic drugs or anti-depressants
- Current or recent use of neuroleptic medication, tricyclic anti-depressants or monoamine oxidase inhibitors
- History of narrow angle glaucoma