Influence of Stroke on the Composition of Intestinal Microbiota "GUTSTROKE"


Phase N/A Results N/A

Trial Description

The aim of the study is to verify the hypothesis that the microbial colonisation of the gut is changed in patients after stroke and that the gut microbiome of severely affected stroke patients differs from that of patients with only a short disruption of blood circulation in the brain (transient ischemic attack, TIA). For this, the composition of gut microbiota in stool samples will be analyzed by 454 pyrosequencing. Further, the correlation of stroke-associated changes in the microbiome with immunological parameters will be analyzed.


Trial Design

  • Observation: Case Control
  • Perspective: Prospective
  • Sampling: Non-Probability Sample

Trial Population

patients at the rescue center, the Stroke Unit and the neurological intensive care unit of the Charité University hospital


Type Measure Time Frame Safety Issue
Primary composition of intestinal microbiome change between day 1, day 4, day 7, day 14 after stroke No
Secondary test of correlation between most changed group of bacteria with changes in immunological parameters (HLA-DR) days 1, 4, 7 after stroke No

Biospecimen Retention:Samples With DNA - Stool samples, Blood samples