Influence of Brain Oscillation-Dependent TMS on Motor Function

Recruiting

Phase N/A Results N/A

Eligibility Criteria

- INCLUSION CRITERIA:
- Healthy young adults:
- Age 18-59
- Willingness/ability to provide informed consent
- Healthy older adults:
- Age 60 and over
- Willingness/ability to provide informed consent
Stroke patients:
- Age 18 and over
- Mild to moderate unilateral or bilateral upper limb hemiparesis
- Stroke onset > 6 months prior to participation
- Intact M1 sufficient to induce motor evoked potentials in the affected hand/wrist following ipsilesional TMS, as evaluated during the TMS Screening.
- Willingness/ability to provide informed consent
- If the investigator feels the individual s capacity to provide informed consent is questionable, the NIH Human Subjects Protection Unit (HSPU) will be requested to determine the individual s ability to consent.
EXCLUSION CRITERIA:
- Healthy young adults:
- Presence of severe neurological or medical disorder (e.g. Parkinson s disease or multiple sclerosis)
- History of seizures
- Chronic use of antipsychotic drugs (e.g., chlorpromazine or clozapine), tri-cyclic or other anti-depressants, benzodiazepines or prescription stimulants
- MRI contraindications, as per NMR Center MRI Safety Screening Questionnaire, such as metal implants and pregnancy. Pregnancy for women of childbearing potential will be assessed using pregnancy test within 24 hours preceding MRI procedures.
- TMS contraindications, such as:
- Pacemaker, implanted pump, stimulator, cochlear implant, or metal objects inside the eye or skull
- Hearing loss
- Staff from our section
- Healthy older adults:
- Presence of severe neurological or medical disorder (e.g. Parkinson s disease or multiple sclerosis)
- History of seizures
- Chronic use of antipsychotic drugs (e.g., chlorpromazine or clozapine), tri-cyclic or other anti-depressants, benzodiazepines or prescription stimulants
- MRI contraindications, as per NMR Center MRI Safety Screening Questionnaire, such as metal implants and pregnancy. Pregnancy for women of childbearing potential will be assessed using pregnancy test within 24 hours preceding MRI procedures.
- TMS contraindications, such as:
- Pacemaker, implanted pump, stimulator, cochlear implant, or metal objects inside the eye or skull
- Hearing loss
- Staff from our section
- Stroke patients:
- Presence of severe neurological or medical disorder, other than stroke (e.g. Parkinson s disease or multiple sclerosis)
- History of brainstem stroke
- History of seizures
- Chronic use of antipsychotic drugs (e.g., chlorpromazine or clozapine), benzodiazepines or prescription stimulants
- MRI contraindications, as per NMR Center MRI Safety Screening Questionnaire, such as metal implants and pregnancy. Pregnancy for women of childbearing potential will be assessed using pregnancy test within 24 hours preceding MRI procedures.
- TMS contraindications, such as:
- Pacemaker, implanted pump, stimulator, cochlear implant, or metal objects inside the eye or skull
- Hearing loss
- Staff from our section