Incidence of Acute Cerebrovascular Events Using Either Minimized or Standard Cardiopulmonary Bypass Circuit "ROCsafeTM"


Phase 4 Results N/A

Eligibility Criteria

Inclusion Criteria

- Patient is older than 17 years
- Patient is acceptable candidate for CABG operation
- Patient or the patient's legal representative has been informed of the nature of the study and agrees to its provisions and has provided written informed consent.

Exclusion Criteria

- Ejection fraction less than 30 %
- Valve surgery
- Acute endocarditis or history of endocarditis
- Cerebral ischemia within 4 weeks before surgery
- Detection of intracardial thrombi in preoperative echocardiography
- Stenosis of A. carotis int. greater than 70 %
- Patients older than 80 years
- Patients on dialysis
- Acute myocardial ischemia or infarction within two weeks before inclusion
- Markedly elevated baseline C-reactive protein (CRP) or leucocytosis
- Cancer or immunologic diseases
- Dysregulation of the coagulation cascade (not concerning INR or PTT under cumarin or heparin treatment)
- Intake of steroids or NSAR
- Female of childbearing potential
- Participation in an other study
- Contraindication for MRI (e.g. pacemaker, any kind of implanted metal)
- Claustrophobia