We hope to understand the properties of the motor cortex in the brain of people with stroke using non-invasive magnetic stimulation.
This case series assesses the effects of five consecutive days of low‐frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) with and without a 6‐Hz primer. Although this paper studies able‐bodied individuals, similar rTMS protocols are used to facilitate motor recovery in patients with hemiplegia following stroke. However, the cortical mechanisms associated with repeated daily doses of rTMS are not completely understood.
- Repetitive Transcranial Magnetic Stimulation Device
Intervention Desc: We will position a coil over the motor cortex of the head and give a series of stimulations (called magnetic pulses). ARM 1: Kind: Experimental Label: 1 Description: Receive rTMS ARM 2: Kind: Experimental Label: 2 Description: Receive sham rTMS ARM 3: Kind: Experimental Label: Arm 1 Description: Receive rTMS ARM 4: Kind: Experimental Label: Arm 2 Description: Receive sham rTMS ARM 5: Kind: Experimental Label: Primed rTMS Description: Receive 10 min. of 6-Hz rTMS Repetitive Transcranial Magnetic Stimulation at 90% RMT (3,600 pulses). Followed by 30 min. of 1-Hz rTMS at 95% RMT (1,880 pulses) ARM 6: Kind: Experimental Label: Unprimed rTMS) Description: Receive 10 min. of sham rTMS Repetitive Transcranial Magnetic Stimulation. Followed by 30 min. of 1-Hz rTMS at 95% RMT (1,880 pulses)
- Allocation: Randomized
- Masking: Double Blind (Subject, Outcomes Assessor)
- Purpose: Treatment
- Endpoint: Safety Study
- Intervention: Parallel Assignment
|Type||Measure||Time Frame||Safety Issue|
|Primary||Percentage BOLD (Blood-oxygen-level Dependent Contrast Imaging) Signal From Baseline at 2 Weeks||Baseline (day 0) and 2 weeks||No|