Improving Motor Stroke Recovery Using Patient-tailored Non-invasive Brain Stimulation

Recruiting

Phase N/A Results N/A

Trial Description

Many individuals are often left with problems moving their arm and hand, months to even years after a stroke. Recent progress in research suggests the application of non-invasive brain stimulation, such as transcranial direct current stimulation (TDCS), in conjunction with rehabilitation exercises can further improve a person's ability to move after stroke. However, the problem is that this doesn't work for everyone, and researchers do not know why. One reason may be that TDCS is currently applied using a one-size-fits-all approach. Researchers apply the same type of TDCS to everyone, assuming the stroke affects everyone in the same way. But, researchers know this is not the case. For example, each person will likely have different amounts of damage to brain regions that control movements. A better understanding of how the stroke uniquely affects a person's brain will help us to know which is the correct type of TDCS to apply for that person. Therefore, the objective of this research is to determine whether the amount of damage to brain regions that control movements can predict which type of TDCS will be more effective to help a person improve their ability to move. Participants will undergo 1 session of magnetic resonance imaging, and three sessions of TDCS.

Conditions

Interventions

  • Anodal tDCS Device
    Intervention Desc: Excitatory stimulation is applied to the unaffected motor cortex while participants perform rehabilitation exercises for the upper extremity
    ARM 1: Kind: Experimental
    Label: Brain Stimulation
    Description: Patients will receive, Sham TDCS, Anodal TDCS, Cathodal TDCS, and Magnetic Resonance Imaging (MRI).
  • Cathodal tDCS Device
    Intervention Desc: Inhibitory stimulation is applied to the unaffected motor cortex while participants perform rehabilitation exercises for the upper extremity
    ARM 1: Kind: Experimental
    Label: Brain Stimulation
    Description: Patients will receive, Sham TDCS, Anodal TDCS, Cathodal TDCS, and Magnetic Resonance Imaging (MRI).
  • Sham tDCS Device
    Intervention Desc: Placebo stimulation is applied to the unaffected motor cortex while participants perform rehabilitation exercises for the upper extremity
    ARM 1: Kind: Experimental
    Label: Brain Stimulation
    Description: Patients will receive, Sham TDCS, Anodal TDCS, Cathodal TDCS, and Magnetic Resonance Imaging (MRI).
  • Magnetic Resonance Imaging (MRI) Device
    Intervention Desc: Participants will receive a MRI of their brain to allow the research investigators to determine how the stroke has affected regions of the brain processing movements.
    ARM 1: Kind: Experimental
    Label: Brain Stimulation
    Description: Patients will receive, Sham TDCS, Anodal TDCS, Cathodal TDCS, and Magnetic Resonance Imaging (MRI).

Trial Design

  • Masking: Open Label
  • Purpose: Treatment
  • Endpoint: Efficacy Study
  • Intervention: Single Group Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Change in movement time (seconds) for reaching after 1 session of TDCS 1 day No
Primary Change in accuracy of reaching (root mean square error) after 1 session of TDCS 1 day No
Primary Change in efficiency of reaching (number of velocity peaks) after 1 session of TDCS 1 day No

Sponsors