Inclusion Criteria1. Acute brain injury due to non-traumatic causes (stroke, spontaneous intracranial hemorrhage, cerebral edema, anoxic brain injury) or traumatic brain injury.
2. Initiation of mechanical ventilation in the emergency department or intensive care unit at an Intermountain Healthcare hospital
3. Age ≥ 18 years
Exclusion Criteria1. Transition to comfort care in the emergency department or on the same day of admission to the ICU
2. Death on the same day of admission to the emergency department or ICU