Impact of Neutrophil Activation in Acute Ischemic Stroke Patients Treated With Endovascular Therapy "NEUTROSTROKE"


Phase N/A Results N/A

Trial Description

Clinical and experimental data suggest that neutrophil activation and extravasation are deleterious in acute ischemic stroke (AIS) involving an increased risk of unfavorable outcome and hemorrhagic transformation (HT). However, clinical trials targeting neutrophil recruitment in AIS patients were negative. Recently, an experimental study has shown that neutrophil activation and transmigration begin immediately after the occlusion. Inhibition of neutrophil recruitment several hours after the start of ischemia appears therefore too late to have a clinical relevance.
The objective is to study the time dependent impact of neutrophils in AIS and the predominant mediators in each time point to identify the appropriate therapeutic target and time window.


Trial Design

  • Perspective: Cross-Sectional
  • Sampling: Non-Probability Sample

Trial Population

Patients with acute ischemic stroke secondary to a large vessel occlusion, undergoing endovascular therapy.


Type Measure Time Frame Safety Issue
Primary neutrophil counts before recanalization No
Primary neutrophil protease counts before recanalization No
Primary recanalization score immediately after endovascular procedure
Primary acute ischemic stroke etiology within 24 hours after endovascular procedure
Primary severity of neurologic symptoms baseline
Primary disruption of the blood-brain-barrier within 24 hours after endovascular procedure
Primary brain haemorrhage 24 hours after endovascular procedure
Primary Recovery of motor function after stroke 3 months No
Primary mortality 3 months
Primary adhesion molecules counts before recanalization No
Primary free plasma DNA counts before recanalization No