Impact of Hemiplegia Due to Stroke on the Microarchitecture of the Bone

Terminated

Phase N/A Results N/A

Trial Description

In hemiplegic, there is very little data on the impact of neurological deficit on the microarchitecture independent of bone mineral density and composition of the bone marrow. Rare studies have shown the relationship between some micro-architectural parameters and severity of neurological deficit. There is no study in humans on the evolution of the parameters of the microarchitecture assessed by 3D micro-tomography in the early phase of the installation of neurological deficits after stroke, in terms of a bearing bone, tibia, that a non-load bearing bones, radius.

Detailed Description

Each patient must answer several questionnaires about their calcium intake and its ability to perform everyday tasks. They will also have 3 blood samples (15 ml each time), 3 measure of bone by 3D micro-tomography and 2 MRI examination. These examinations and sampling will take place after 30 days after stroke onset (except for MRI) and again after three months and six months after the stroke (the same day as the medical follow-up visit).

Trial Stopped: Inclusion rhythm too slow

Conditions

Interventions

  • MRI and 3D CT scan Procedure
    Intervention Desc: Measurement of bone microarchitecture at the legs and wrists by 3D CT Scan and measuring the proportion of fat in the imaging leg bone (MRI)
    ARM 1: Kind: Experimental
    Label: Patients
    Description: Patients who have experienced a vascular hemiplegia and accept bone measure by MRI and 3D CT scan

Trial Design

  • Observation: Cohort
  • Perspective: Prospective
  • Sampling: Non-Probability Sample

Trial Population

Patient aged at least 30 who have experienced a vascular hemiplegia within 30 days before enrollment

Outcomes

Type Measure Time Frame Safety Issue
Primary Bone volume / tissue volume 90 days Yes
Secondary intraosseous fat 90 days Yes

Biospecimen Retention:Samples With DNA - blood sample

Sponsors