Impact of Anesthesia Type on Outcome in Patients With Acute Ischemic Stroke (AIS) Undergoing Endovascular Treatment

Not yet recruiting

Phase N/A Results N/A

Trial Description

Recent observational studies have found an association between general anaesthesia and increased post-operative mortality in acute ischemic stroke patients undergoing endovascular treatment. It is unknown whether there is a causal relationship in this observation. The investigators are performing a large randomised trial of general versus local anaesthesia to definitively answer the question of whether anaesthetic type alters perioperative outcome.

Conditions

Interventions

  • Local anesthesia Procedure
    ARM 1: Kind: Experimental
    Label: Local anesthesia
    Description: local anesthesia and spontaneous breathing will be maintained.
  • Intravenous anesthetics Other
    ARM 1: Kind: Experimental
    Label: General anesthesia
    Description: Intravenous anesthetics and controlled ventilation will be used .
  • Controlled ventilation Procedure
    ARM 1: Kind: Experimental
    Label: General anesthesia
    Description: Intravenous anesthetics and controlled ventilation will be used .
  • Spontaneous breathing Other
    ARM 1: Kind: Experimental
    Label: Local anesthesia
    Description: local anesthesia and spontaneous breathing will be maintained.

Trial Design

  • Allocation: Randomized
  • Masking: Single Blind (Outcomes Assessor)
  • Purpose: Supportive Care
  • Endpoint: Efficacy Study
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary modified Rankin score post-procedural 30 days No

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