We hypothesized that paradoxical embolism may be one of the main mechanisms of silent cerebral infarction (SCI) located outside the perforating artery territory. In the present study, we evaluated the association between SCI and paradoxical embolism detected by agitated saline transcranial Doppler (TCD) monitoring in healthy subjects without history of stroke or transient ischemic attack (TIA). We also compared the frequency and amount of paradoxical embolism between healthy subjects with SCI and acute stroke patients with presumed cryptogenic embolism or conventional stroke mechanisms.
- Observation: Case Control
- Perspective: Prospective
- Sampling: Probability Sample
|Type||Measure||Time Frame||Safety Issue|
|Primary||Frequency and amount of right-to-left shunts (RLS) on agitated saline TCD monitoring||Within a month after MRI scanning||No|