Identification the Cause of Silent Cerebral infarctiON in Healthy Subjects (ICONS) "ICONS"


Phase N/A Results N/A

Trial Description

We hypothesized that paradoxical embolism may be one of the main mechanisms of silent cerebral infarction (SCI) located outside the perforating artery territory. In the present study, we evaluated the association between SCI and paradoxical embolism detected by agitated saline transcranial Doppler (TCD) monitoring in healthy subjects without history of stroke or transient ischemic attack (TIA). We also compared the frequency and amount of paradoxical embolism between healthy subjects with SCI and acute stroke patients with presumed cryptogenic embolism or conventional stroke mechanisms.


Trial Design

  • Observation: Case Control
  • Perspective: Prospective
  • Sampling: Probability Sample

Trial Population

Tertiary Hospital


Type Measure Time Frame Safety Issue
Primary Frequency and amount of right-to-left shunts (RLS) on agitated saline TCD monitoring Within a month after MRI scanning No