Identification of Stroke Patients ≤ 3 and ≤ 4.5 Hours of Symptom Onset by Fluid Attenuated Inversion Recovery (FLAIR) Imaging and Diffusion Weighted Imaging (DWI) "PRE-FLAIR"

Completed

Phase N/A Results N/A

Trial Description

The aim of the study is to evaluate the use of combined fluid attenuated inversion recovery (FLAIR) imaging and diffusion weighted imaging (DWI) as surrogate marker of lesion age within the first 6 hours of ischemic stroke in order to identify patients ≤ 3 or ≤ 4.5 hours of symptom onset in a large multicenter study hours of ischemic stroke. The investigators hypothesize that the pattern of a visible lesion on DWI together with a negative FLAIR ("DWI-FLAIR mismatch") will identify patients ≤ 3 hours of symptom onset with >80% specificity and positive predictive value.

Conditions

Trial Design

  • Observation: Cohort
  • Perspective: Cross-Sectional
  • Sampling: Non-Probability Sample

Trial Population

Patients with acute ischemic stroke confirmed by acute or follow-up MRI with defined and well known symptom onset

Outcomes

Type Measure Time Frame Safety Issue
Primary Specificity (and 95% CI) of "DWI-FLAIR-mismatch" for the identification of patients ≤3 and ≤4.5 hours on admission No
Secondary Predictors of a "negative FLAIR" in acute ischemic stroke on admission No

Sponsors