Acute ischemic stroke, intravenous rt-PA within 4.5h after symptom onset, age 18-80, NIHSS 2-20, item 1a on NIHSS ? 1, written informed consent.
Contraindications to hypothermia (e.g. vasospastic disorders or coagulopathies), medical conditions likely to complicate therapy (e.g. uncompensated arrhythmia, severe heart failure, severe liver or renal insufficiency).