Hybrid Approach to Unilateral vs. Bilateral Upper Limb Rehabilitation in Subacute and Chronic Stroke


Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

- 1 to 6 months onset from a first-ever unilateral stroke for the subacute randomized controlled trial (RCT), and more then 6 months after onset for the chronic RCT
- minimal motor criteria to receive CIT (i.e., ≥10º wrist extension and ≥ 10º extension at the thumb and any two other digits)
- an initial FMA-UE score of 18 to 56, indicating mild to moderate and moderate to severe upper extremity motor impairment
- no excessive spasticity in any of the joints of the affected arm (shoulder, elbow, wrist, and fingers)
- able to follow instructions and perform the study tasks (Mini Mental State Examination ≥ 24)
- without upper extremity fracture within 3 months
- no participation in any rehabilitation experiments or drug studies during the study period
- willing to provide written informed consent

Exclusion Criteria

- acute inflammatory disease
- major health problems or poor physical condition that might limit participation